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Search Results for " carbonic anhydrase xii "

Targets Recommended: Carbonic Anhydrase

31

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36758	CAIX Inhibitor S4 S4	Carbonic Anhydrase	Metabolism
	CAIX Inhibitor S4 (S4) 是一种有效的碳酸酐酶 IX/XII 抑制剂，Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。
T63305	Carbonic anhydrase inhibitor 6	Carbonic Anhydrase	Metabolism
	Carbonic anhydrase inhibitor 6 是一种高效的人碳酸酐酶 (hCA) 抑制剂，抑制 hCA IX，hCA II，hCA XII和hCA I，可用于研究碳酸酐酶异常引起的疾病。
T77631	Enpp/Carbonic anhydrase-IN-2	Apoptosis; PDE; Carbonic Anhydrase	Apoptosis; Metabolism
	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
T2017	U-104 NSC-213841,MST-104	Carbonic Anhydrase	Metabolism
	U-104 (NSC-213841) 是 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂，其 Ki 分别为 45.1 nM 和 4.5 nM。小鼠模型中，它能够表现出明显的抑制肿瘤生长的作用。
T73177	hCAII-IN-9	Carbonic Anhydrase	Metabolism
	hCAII-IN-9 是一种强效的碳酸酐酶抑制剂，对hCA II、hCA IX 和hCA XII 有抑制作用，IC50 分别为 1.18 μM 和 0.17 μM , and 2.99 μM 。hCAII-IN-9 没有血脑屏障透过性。
T61745	hCAI/II-IN-6	Carbonic Anhydrase	Metabolism
	hCAI/II-IN-6 是一种具有选择性和口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6对 hCA I，hCA II，hCA VII 和 hCA XII 有抑制作用，Ki 值分别为 220，4.9，6.5 和＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性。hCAI/II-IN-6 可以用于研究癫痫。
T62666	Carbonic anhydrase inhibitor 7
	Carbonic anhydrase inhibitor 7 是一种人碳酸酐酶 (hCA) 的有效抑制剂，作用于 hCA IX (Ki: 6.5 nM)，hCA II (Ki: 7.1 nM)，hCA XII (Ki: 72.1 nM) 和 hCA I (Ki: 255.8 nM)。
T62026	hCAIX-IN-11
	hCAIX-IN-11 (Compound 5d) 是选择性的碳酸酐酶 (carbonic anhydrase) IX 和 XII 抑制剂。hCAIX-IN-11抑制 hCA IX 和 hCA XII 的Ki 分别为 32.7 和 623.5 nM。
T72164	Enpp/Carbonic anhydrase-IN-2
	Enpp/Carbonic anhydrase-IN-2 是一种有效的 Enpp 和 carbonic anhydrase 抑制剂，对 NPP1、NPP2、NPP3、CA-IX, CA-XII 的 IC50值分别 1.13、 1.07、 0.74、 0.33、 0.68。Enpp/Carbonic anhydrase-IN-2 对癌细胞具有抗增殖活性，对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-2 诱导细胞凋亡 (Apoptosis)。
T62976	Carbonic anhydrase inhibitor 5
	Carbonic anhydrase inhibitor 5 是一种有效的、选择性的人碳酸酐酶 (hCA) 抑制剂，能够作用于 hCA II (IC50: 42.9 nM)、hCA IX (IC50: 47.6 nM) 和 hCA XII (IC50: 6.7 nM)。
T63005	Carbonic anhydrase inhibitor 11
	Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的、选择性碳酸酐酶抑制剂，能够作用于 CA II (Ki: 40 nM)、CA IX (Ki: 39 nM) 和 CA XII (Ki: 900 nM)。
T63158	hCAIX-IN-10
	hCAIX-IN-10 (Compound 6i) 是一种选择性碳酸酐酶 IX 和 XII 抑制剂，作用于 hCA IX (Ki: 61.5 nM) 和 hCA XII (Ki: 586.8 nM)。其中 hCA IX 和 hCA XII 是一种跨膜同工型碳酸酐酶，能够作为一些类型肿瘤的生物标志物。hCA XII 有助于正常细胞和肿瘤细胞中酸碱平衡的维持。
T61842	Carbonic anhydrase inhibitor 14
	Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibits CDK2 with an IC 50 of 20.3 μM. Furthermore, Carbonic anhydrase inhibitor 14 demonstrates significant antitumor activity [1].
T63973	hCAXII-IN-3
	hCAXII-IN-3 (Compound 6o) 是人碳酸酐酶 XII（hCAXII）的选择性抑制剂 (Ki: 10.0 nM)。
T62101	hCAXII-IN-2
	hCAXII-IN-2 (compound 5i) 是一种人碳酸酐酶 XII (hCA XII) (Ki: 84.2 nM) 和 hCA IX (Ki: 268.5 nM) 的有效抑制剂，对 hCA I 和 hCA II 具有较低的活性。
T83137	ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase	Metabolism
	ALP/Carbonic anhydrase-IN-1（Compound 1e）为碳酸酐酶（CA）与碱性磷酸酶（ALP）的双效抑制剂。对CA-II、CA-IX、CA-XII和ALP具有显著抑制活性，其IC50值分别为0.44 µM、1.61 µM、0.51 µM和0.107 µM。
T72840	hCAIX/XII-IN-6
	hCAIX/XII-IN-6 是具有口服活性的碳酸酐酶（CA）抑制剂，能够抑制人体 CA 亚型 hCA I、II、IV、IX 及 XII，其 Ki 值分别为 6697 nM、2950 nM、4093 nM、4.1 nM 和 7.7 nM。适用于类风湿关节炎（RA）研究。
T79411	hCAXII-IN-7	Carbonic Anhydrase	Metabolism
	hCAXII-IN-7 (compound 6e)为hCA XII抑制剂，且具备脑屏障通透性。此化合物能够诱导786-0、SF-539和HS 578 T细胞系的凋亡。
T62755	HCAIX-IN-2
	HCAIX-IN-2 (compound 9d) 是一种碳酸酐酶的选择性抑制剂，能够作用于 hCA IX (Ki: 24.6 nM) 和 hCA XII (Ki: 45.3 nM)。
T78789	hCA XII-IN-6	Carbonic Anhydrase	Metabolism
	hCA XII-IN-6（化合物4d）是一种具有84.2 nM Ki值的hCA XII强效抑制剂，显示出抗增殖活性，并可用于癌症的研究。
T60602	hCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂，具有出色的 hCA IX/XII 选择性，对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性，可延迟细胞周期并诱导细胞凋亡。
T79748	hCAIX/XII-IN-7	Carbonic Anhydrase	Metabolism
	hCAIX/XII-IN-7（compound 3e）为高效的hCA IX与XII抑制剂，对hCA I、II、IX与XII的Ki值分别为3.2 nM、9.2 nM、503.7 nM及59 nM，显示其在缺氧肿瘤研究中的应用潜力。
T61164	hCAII-IN-3
	hCAII-IN-3 (Compound 16) is an inhibitor of human carbonic anhydrase (hCA). It exhibits high affinity for hCA I, hCA II, hCA IX, and hCA XII, with Ki values of 403.8 nM, 5.1 nM, 10.2 nM, and 5.2 nM, respectively. Notably, hCA IX-IN-2 demonstrates anticancer activity [1].
T61263	hCA IX-IN-1
	hCA IX-IN-1 (Compound 6f) 是一种人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IX 和 hCA XII 的 Ki 值分别为 331.4、28.4、9.4 和 17.8 nM。
T63631	hCAII-IN-2
	hCAII-IN-2 是胞质型人碳酸酐酶 (hCA) 抑制剂，能够作用于 hCA I (Ki: 261.4 nM)、hCA II (Ki: 3.8 nM)、hCA IX (Ki: 19.6 nM)和 hCA XII (Ki: 45.2 nM)。
T63764	hCA XII/II/IX-IN-1
	hCA XII/II/IX-IN-1 是人碳酸酐酶 (hCA) 的有效抑制剂，能够作用于 hCA I (IC50: 2.6 μM)、 hCA II (IC50: 0.004 μM)、hCA IX (IC50: 0.005 μM) 和 hCA XII (IC50: 0.001 μM)。hCA XII/II/IX-IN-1 表现出抗癌效果。
T79540	hCA/VEGFR-2-IN-1	Carbonic Anhydrase	Metabolism
	hCA/VEGFR-2-IN-1 是一种高效的双靶点抑制剂，对 hCA IX 和 hCA XII 两种碳酸酐酶（CA）具有极低的Ki值，分别为8.3 nM和4.7 nM。同时，hCA/VEGFR-2-IN-1 也是一种有效的 VEGFR-2 抑制剂，其 IC50 值仅为26.3 nM，并且显示出抗癌活性。
T74486	hCAIX-IN-17
	hCA IX-IN-1 (Compound 6f) 是一种人碳酸酐酶 (hCA) 抑制剂，对hCA I、hCA II、hCA IX 和hCA XII 的Ki 值分别为 331.4、28.4、9.4 和 17.8 nM。
T63400	hA2A/hCA XII modulator 1
	hA2A/hCA XII modulator 1 是 hA2A 腺苷受体 (hA2AAR) 的有效拮抗剂，是一种三唑并吡嗪，能够作用于hA2AAR (Ki: 6.4 nM)、hA1AR (Ki: 4.819 μM)、hA3AR (Ki>30 μM)。hA2A/hCA XII modulator 1 也人碳酸酐酶 XII (hCA XII) 的有效抑制剂，能够作用于 hCA XII (Ki: 6.2 nM)、hCA II (Ki: 46 nM)、hCA IX (Ki: 466 nM) 和 hCA I (Ki: 8.351 μM)。hA2A/hCA XII modulator 1 表现出研究癌症的潜力。
T78705	COX-2-IN-30	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-30 是苯磺酰胺衍生的口服活性 COX/5-LOX 双重抑制剂，其 IC50 值为 COX 同源物为 49 nM、5-LOX 同源物为 10.4 μM。此化合物还能纳摩尔级别 Ki 值抑制 hCA IX 与 hCA XII 亚型。COX-2-IN-30 具备镇痛、抗炎、致溃疡作用，不引发急性胃部反应。
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an...

化合物

CAIX Inhibitor S4

Cat.No: T36758

Synonym: S4

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 6

Cat.No: T63305

Target: Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-2

Cat.No: T77631

Target: Apoptosis, PDE, Carbonic Anhydrase

Cat.No: T2017

Synonym: NSC-213841,MST-104

Target: Carbonic Anhydrase

Cat.No: T73177

Target: Carbonic Anhydrase

Cat.No: T61745

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 7

Cat.No: T62666

Cat.No: T62026

Enpp/Carbonic anhydrase-IN-2

Cat.No: T72164

Carbonic anhydrase inhibitor 5

Cat.No: T62976

Carbonic anhydrase inhibitor 11

Cat.No: T63005

Cat.No: T63158

Carbonic anhydrase inhibitor 14

Cat.No: T61842

Cat.No: T63973

Cat.No: T62101

ALP/Carbonic anhydrase-IN-1

Cat.No: T83137

Target: Carbonic Anhydrase

hCAIX/XII-IN-6

Cat.No: T72840

Cat.No: T79411

Target: Carbonic Anhydrase

Cat.No: T62755

Cat.No: T78789

Target: Carbonic Anhydrase

hCAIX/XII-IN-5

Cat.No: T60602

hCAIX/XII-IN-7

Cat.No: T79748

Target: Carbonic Anhydrase

Cat.No: T61164

Cat.No: T61263

Cat.No: T63631

hCA XII/II/IX-IN-1

Cat.No: T63764

hCA/VEGFR-2-IN-1

Cat.No: T79540

Target: Carbonic Anhydrase

Cat.No: T74486

hA2A/hCA XII modulator 1

Cat.No: T63400

Cat.No: T78705

Target: COX

Chlorthalidone Impurity G

Cat.No: T35876

Cat. No.	Product Name	Target	Signaling Pathways
T40611	(E)-Dehydrodiconiferyl alcohol
	(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibitory effects on the nuclear translocation of NF-κB in the connective tissue of the healing area.

天然产物

(E)-Dehydrodiconiferyl alcohol

Cat.No: T40611

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00694	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) HsT18816,FLJ20151,carbonic anhydrase X...	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1.
TMPY-00688	Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His) AI314958,Car12,2310047E01Rik,carbonic anhydrase...	Mouse	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q8CI85.
TMPK-00478	Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His) CA12,CAXII,Carbonic anhydrase,CA-...	Cynomolgus	HEK293 Cells
	Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in cancer development.
TMPY-06944	Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated HsT18816,carbonic anhydrase XII,C...	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.45 kDa and the accession number is NP_001209.1.

重组蛋白

Carbonic Anhydrase 12 Protein, Human, Recombinant (His)

Cat.No: TMPY-00694

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00688

Species: Mouse

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00478

Species: Cynomolgus

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06944

Species: Human

Expression System: HEK293 Cells

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